METABOLISM

Helps maintain glucose balance

DELPHINOL extract stabilizes blood glucose levels, helping to control metabolic balance. The delphinidins of DELPHINOL have powerful anti- inflammatory effects, due to their activation of the PPAR gamma receptor. This activation mechanism is strongly correlated with the control of Type 2 diabetes, as it enhances insulin sensitivity.

Also, since hyperglycemic episodes in diabetic patients are closely linked to nitro-oxidative or oxidative stress —the most important factor in the onset and progress of vascular and kidney complications from Type 1 and Type 2 diabetes— the potent effect of DELPHINOL® may help prevent the pro-oxidant effects of hyperglycemia.

In conclusion, studies show that the delphinidins of DELPHINOL® significantly increase the expression of adipocytokine genes, PPAR gamma and specific adipocyte genes in humans and can be an excellent complement in regulating the adipocyte function.

Pre-clinical studies and toxicology

DELPHINOL has been subject to pre-clinical trials carried out by senior researchers and collaborators at the Institute of Pharmacology and Morphophysiology at Universidad Austral de Chile, in the city of Valdivia. In these trials, the extract was shown to have anti-aging characteristics, including anti-oxidant, immune-boosting, anti-inflammatory and glycaemia control characteristics.

This graph in brief present the dose-effect size of the three dosages on fasting glucose (similar to the previous slide) and also shows the blood sugar values 30 minutes after consumption of 75 grams of glucose.

Here again it is noticeable that the first 60 mg show the greatest impact. Doubling the dosage is far from doubling the glucose-lowering effect.

And the values for 120 and 180 are essentially of the same size.

3 Months clinical study with pre-diabetic participants

Participants with impaired glucose metabolism (pre-diabetes)

included 36 pre-diabetic participants:

Women and men aged 18 – 50 years, BMI > 23 kgm-2

Inclusion criteria:

  • A basal (stable-overnight) blood glucose concentration greater than 100 mg/dL, or basal insulin > 15 μU/mL.
  • Blood glucose values reaching or exceeding 160 mg/dL at any time.
  • A blood glucose value persisting at ≥ 140 mg/dL over two hours, or insulin values persisting at ≥ 60 μU/mL, for a continuous time period of 120 minutes.

A delphinol dose-finding study for effects on glucose-control has been carried out with 36 pre- diabetic individuals.

prediabetic people were chosen because they respond with higher blood glucose after consumption of a defined amount of glucose

Regular delphinol® intake shows lasting blood glucose lowering

The antioxidant virtues of Delphinol were tested in the overweight individuals by measuring the quantities of oxidised LDL in their blood

Oxidised LDL is an important health parameter because the oxidised LDL sticks to artery wall, where additional bound LDL may, wuth time, generate an atherosclerotic plaque

The average value of glycated hemoglobin of the 36 volunteers was 5.65 at the begining of the trial (baseline). Every 30 days of treatment the levels of HbA1c were measured again and a drop of the values was found.

After 60 days of delphinol supplementation the drop on HbA1c reached statistical significance.

During the same study we observed an improvement on lipidinc profile. Total Cholesterol decrese after 3 months of diet supplementation with delphinol.

HDL values, also knonwn as “good cholesterol” experience a statiscally significant increase since the second month of supplementation.

LDL values, also knonwn as “bad cholesterol” experience a statiscally significant decrease since the third month of supplementation.